The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells
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The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells
![The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells](https://d3i71xaburhd42.cloudfront.net/4df4a9e8b1e6a048142c865b1303721ccaf97e67/4-Figure3-1.png)
PDF] Not only P-glycoprotein: Amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins.
![The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells](https://pubs.acs.org/cms/10.1021/acsbiomedchemau.2c00063/asset/images/large/bg2c00063_0008.jpeg)
Targeted Protein Degradation for Infectious Diseases: from Basic Biology to Drug Discovery
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Exploring new Horizons in overcoming P-glycoprotein-mediated multidrug- resistant breast cancer via nanoscale drug delivery platforms - ScienceDirect
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Full article: Targeting CDK9 with selective inhibitors or degraders in tumor therapy: an overview of recent developments
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October, 2022
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Frontiers Nanodrug delivery in reversing multidrug resistance in cancer cells
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Industry Perspective on the Pharmacokinetic and Absorption, Distribution, Metabolism, and Excretion Characterization of Heterobifunctional Protein Degraders
![The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells](https://pubs.acs.org/cms/10.1021/acsbiomedchemau.2c00063/asset/images/medium/bg2c00063_0001.gif)
Targeted Protein Degradation for Infectious Diseases: from Basic Biology to Drug Discovery
![The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells](https://d3i71xaburhd42.cloudfront.net/5b6fe1f16fae113cca3f8ada1d12e8bdce40a987/6-Table1-1.png)
PDF] Regulations of P-Glycoprotein/ABCB1/MDR1 in Human Cancer Cells
![The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells](https://www.foxchase.org/sites/default/files/JamesDuncan_1200-628.jpg)
Lapatinib May Boost Effectiveness of Drugs That Destroy Cancer Proteins by Blocking Resistance
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Drug resistance: from bacteria to cancer
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Cancers, Free Full-Text
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MDR1 Drug Efflux Pump Promotes Intrinsic and Acquired Resistance to PROTACs in Cancer Cells
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The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells